ActiPix™ SDI300 Surface Dissolution Imaging System

The ActiPix™ SDI300 is a powerful UV area imaging system which enables quantitative imaging of surface phenomena for a diverse range of substances including active pharmaceutical ingredients (APIs), formulations, gels, liquids, suspensions, stents and patches.

Used as a tool for accelerated pre-formulations development, the SDI300 is proven to enable intrinsic dissolution rates to be obtained in less than 20 minutes, a fraction of the time compared to conventional dissolution systems. The dissolution medium can easily be exchanged, e.g. from 0.1 M HCl to a neutral buffer or to an aqueous alcoholic solution.

Compact in design, the SDI300 system includes award-winning ActiPix™ UV area imaging technology, a surface dissolution imaging sample holder, an integrated syringe pump, and software which enables real time quantitative recording and review of data. The SDI300 uses a highly sensitive UV area imaging sensor to record, interrogate and analyse a variety of complex processes.

The ActiPix SDI300 also provides unique insights into processes taking place from microns to millimetres from the surface, the key distance range for understanding dissolution, and enables both erosion and dissolution to be visualized simultaneously.

The optimum wavelength can be selected to allow sensitive and selective monitoring of the substance of interest.

The ActiPix™ SDI300 is the first tool of its kind to offer quantitative and mechanistic information for a variety of applications.

Proper Use Procedures (Do's and Don'ts)

Technical Notes

Real-time measurement of Ca2+ release from bovine tooth sample

Real-time measurement of nicotine release from dermal patch

Rapid determination of intrinsic dissolution rates of sparingly soluble APIs using surface dissolution imaging

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